Pregabalin IMpurity IV
4-Isobutyl-2-pyrrolidinone (pregabalin lactam impurity)
CAS: 61312-87-6
Molecular Formula: C8H15NO
Pregabalin IMpurity IV - Names and Identifiers
Pregabalin IMpurity IV - Physico-chemical Properties
| Molecular Formula | C8H15NO |
| Molar Mass | 141.21 |
| Density | 0.927±0.06 g/cm3(Predicted) |
| Boling Point | 269.1±9.0 °C(Predicted) |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | Colourless to Light Yellow Oil to Low-Melting |
| pKa | 16.66±0.40(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
Pregabalin IMpurity IV - Risk and Safety
| HS Code | 2933790002 |
| Hazard Class | IRRITANT |
Pregabalin IMpurity IV - Reference Information
| Use | The lactam compound 4-isobutyl-2-pyrrolidone is a key intermediate in the synthesis of pregabalin, can be used in the laboratory chemical medicine research and development process. |
| preparation | in 600 of methanol, 50.00G of nitro compound (01) and 18.04G of NiCl2 · 6H2O were added; the solution was cooled to 0-5 °c and 18.2g of sodium borohydride was added. After the addition, the temperature was raised to 40 ° C. To 45 ° C. And the mixture was stirred for 12 hours. Then, the mixture was cooled to room temperature, and hydrochloric acid aqueous solution was added dropwise to adjust pH = 2-3. The reaction solution was concentrated under reduced pressure until the system had no obvious methanol (detected by gas chromatography), and was extracted with ethyl acetate, washed with water, the organic layer was dried and concentrated to obtain lactam compound (02). Isobutyl-2-pyrrolidone, light yellow oil 31.20G, yield 96.0%, purity 99.10%. |
Last Update：2024-04-10 22:29:15
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Product Name: Pregabalin Impurity 33 Visit Supplier Webpage Request for quotationCAS: 61312-87-6
Tel: 0714-3999186
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Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: 4-Isobutyl-2-pyrrolidinone (pregabalin lactam impurity) Visit Supplier Webpage Request for quotation
CAS: 61312-87-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 61312-87-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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